Membrane Reorganization during Fungal Synapse Formation. From the lab of STMC member Aaron Neumann.
Signaling for Innate Immune Fungal Recognition. From the lab of STMC member Aaron Neumann.
Actin, Golgi, nucleus projection image. From the lab of STMC leader Diane Lidke.
Single molecule FISH, IL4 mRNA. Images by STMC postdoctoral fellow Cedric Cleyrat and STMC graduate student Emanuel Salazar Cavazos.
Actin (yellow) vs nucleus (blue). Images by STMC postdoctoral fellow Cedric Cleyrat.
PitStop - treated cell. Images by STMC postdoctoral fellow Cedric Cleyrat.
PitStop2 treated RBL cell. Images by STMC postdoctoral fellow Cedric Cleyrat.
Images by STMC postdoctoral fellow Cedric Cleyrat.
Images from the lab of STMC leader Diane Lidke
Images from Chris Valley, Lidke Lab.
Tumor Modeling. Images from Kim Kanigal, Wilson Lab.
The New Mexico Center for the Spatiotemporal Modeling of Cell Signaling (STMC) is an interdisciplinary, inter-institutional program with two principal scientific goals: 1) to understand cell membrane spatial organization and dynamics; 2) to determine how the spatial proximity, dynamics, interactions and biochemical modifications of membrane receptors and signaling proteins together determine the outcome of complex, interacting cell signaling networks important in immune system diseases and cancer. View our Research Highlights
April 2: "Single molecule imaging and FRET microscopy reveal that enhanced dimerization drives oncogenic activity of EGFR NSCLC mutants", Diane S. Lidke, PhD, Associate Professor, Pathology, UNM and "Sequential superresolution imaging of multiple targets using a single fluorophores", Keith A. Lidke, PhD, Associate Professor, Physics & Astronomy, UNM. 12:00 PM, UNM Cancer Center Auditorium.
The STMC will host the 2015 Annual Meeting of the National Centers for Systems Biology (NCSB) (July 9-10, 2015). Follow this link to agenda, registration and lodging.
About the STMC: Our research emphasizes the development of new single cell and single molecule technologies to generate improved quantitative data for modeling and the creation of new computational and mathematical tools for image analysis, hypothesis generation and prediction. We support training and outreach programs intended to recruit and equip a new generation of interdisciplinary researchers for successful careers focused on quantitative, systems level analyses of complex biomedical processes. Our infrastructure is designed to sustain systems biology research and training as a long-term area of scientific emphasis at the University of New Mexico (UNM) and in the partnering Los Alamos National Laboratories (LANL) and Sandia National Laboratories (SNL) and to lead the advancement of women and minorities within the discipline of systems biology. The STMC is one of 14 National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS).