National Centers for Systems Biology National Institutes of Health Sandia National Laboratories Los Alamos National Laboratory UNM Cancer Center The University of New Mexico New Mexico Consortium
© Copyright 2012 The New Mexico Center for the Spatiotemporal Modeling of Cell Signaling

Data Analysis and Modeling Software Interest Group (DAMSIG)

Purpose:

The current task for the DAMSIG group is to create stochastic simulation software that can analyze and model the data on spatial distributions of receptors and signaling molecules generated by STMC experimental biologists. The data are of two types: TEM images of 5-10 nm gold particles marking the location of receptors and the proteins and lipids that associate with them (static data) and single particle tracking images of quantum dots conjugated to receptors and signaling proteins on live cells (dynamic data). As new single molecule imaging technologies are developed in the Quantitative Imaging core, the DAMSIG group expects to contribute to more complex data analysis and modeling challenges, including the improved analysis of data from hyperspectral and Super-Resolution microscopy.

DAMSIG Spring 2012 Schedule

We meet Thursdays from 1:00 PM to 3:00 PM (+-) in CRF 104. This is a conference room with a projector. Map to CRF (Cancer Research Facility) pdf icon

MAY 03
Kimberly Kanigel-Winner
1:00 PM in CRF 104
Kimberly Kanigel-Winner will present.
Download the Kimberly Kanigel-Winner abstract, "Ovarian cancer relapse: micro-carcinomas vary in form with peritoneal niche" pdf icon.

APRIL 26
Flor Espinoza
1:00 PM in CRF 104
Flor Espinoza will present a talk on her analysis of static and dynamics membrane data.

APRIL 19
Arnaud Chauviere
1:00 PM in CRF 104
Title: Modeling cell migration in the extracellular matrix

Abstract: Cell migration is an essential feature of both normal and pathological biological phenomena. Cells interact with both other cells and the surrounding tissue (the extracellular matrix or ECM). The ECM serves many functions, such as providing support and anchorage for cells; It is composed of an interlocking mesh of fibrous proteins as collagen and provides directional information through the fibers along which cells tend to align. Various cell migratory behaviors in the ECM have been identified. In this presentation, we focus on the amoeboid migration, i.e. when cells migrate by using the ECM as a scaffold and squeeze into free spaces of the matrix, frequently changing direction and leaving the fibers almost unaltered. We present a mesoscopic framework of transport equations for velocity-jump processes including the alignment process along the fibers and cell-cell interactions leading to random movement reorientation. The model is extended to account for the influence of environmental factors (e.g. chemotaxis). The corresponding macroscopic continuum models are derived by appropriate rescaling, which leads to the so-called diffusive approximation. We present numerical simulations of these models and evidence the influence of the ECM heterogeneity and anisotropy on cell migration.

CV: http://pathology.unm.edu/faculty/faculty/arnaud-chauviere.html
Personal webpage: http://www.achauviere.com/

MARCH 29
Brad Peercy will present at 1:00 PM
Brad is a math bio person visiting the mathematics dept.
Title: "A Force Balance Model of Border cell Migration in Drosophila Oogenesis"
CV: http://www.math.umbc.edu/people/peercy.htm
CRF 104

Home > Events > Meetings > Data Analysis and Modeling Software Interest Group
New Mexico Center for the SpatioTemporal Modeling of Cell Signaling