Many biological experiments are performed on groups of cells, under the assumption that all cells of a particular "type" are identical. However, individual cells within the same population may differ dramatically as a function of cell cycle stage or microenvironment, and these differences can have important consequences for the health and function of the entire population. Furthermore, individual cells can exhibit enormously heterogeneous behavior from one region to another, as shown for example by evidence for lipid rafts and protein islands that segregate membrane components into microdomains with distinct compositions and functions. Imaging single molecules allows the measurement of quantitative parameters, such as the number of molecules, reaction rate constants and diffusion coefficients, at the subcellular level with spatial distributions and temporal fluctuations. This detailed information is essential for constructing quantitative models of reaction networks that provide a systems-level understanding of the mechanisms by which various cellular behaviors are emerging.
Understanding Cell Behavior through Single Cell and Single Molecule Biology is a conference in two parts.
Day one will be dedicated to a Symposium on Single Cell/Single Molecule Biology, with invited talks and contributed posters featuring these topics:
Days 2 and 3 will be organized as an interactive Conference on Quantitative Bioimaging, in which tutorials to introduce key problems in Single Molecule Biology and image analysis will be followed by intense discussion and poster sessions.
Participants may register for the Symposium, the Conference or for both events. The event is free, although registration is requested and attendance will be capped at 190 participants (Symposium) and 150 participants (Conference). All participants are encouraged to submit poster abstracts aligned with one of the subject areas.
Parking is available in the UNM Parking and Transportation parking lot (located at 1621 Central Avenue, northwest corner of Central and University Boulevard).
Contact Ryan Tanner via email: firstname.lastname@example.org
We have negotiated special rates with Embassy Suites for the meeting attendees. These rates include breakfast, internet access and transportation to the conference site. The Embassy Suites is the only hotel providing transportation.
Update: The reserved block of rooms has been released by Embassy Suites on December 10, 2013. You can still make hotel reservations using the Group Code "UCC"; however, your reservation will now depend on room availability. The Embassy Suites will do whatever they can to accommodate our conference attendees. Please contact Melinda James directly by email: email@example.com or phone (505) 353-5381.
Make your reservation by phone:
Embassy Suites Albuquerque
1000 Woodward Pl NE
Albuquerque, NM 87102
(505) 245-7100 *direct hotel number
(800) 362-2779 *ask for Embassy Suites Albuquerque
Refer to Group Code: UCC
Reservation issues can be directed to Ms. Melinda James.
Phone: (505) 353-5381
Abstract submission for the January 09 poster session is now open. Please send your abstract to firstname.lastname@example.org. Be sure to indicate the presenting author and affiliations. Abstract submission deadline is December 15, 2013. Several short talks will be selected from the submitted abstracts.
Note that abstract for the January 9 symposium are separate from those for the Jan 10-11 QBI conference. To submit and abstract for the QBI poster session, go to: http://quantitativebioimaging.com/apps/abstractsubmission/
8:00: Registration opens
8:20: bus departs Embassy Suites Hotel
9:00: Jan Burkhardt, University of Pennsylvania. Cytoskeletal control of integrin activation at the immunological synapse - resistance is not futile
9:30: Gleb Shtengel, HHMI/Janelia Farm. Correlative PALM and EM imaging
10:00: Diane Lidke, UNM. Single molecule dynamics of FceRI signaling
10:30: Coffee break
11:00: Kathrin Spendier, University of Colorado, Colorado Springs. Laser‑Directed Deposition of Metal Nanoparticles for Real‑Time Micropattering
11:20: Alessandra Cambi, Nijmegen Centre for Molecular Life Sciences. Dynamics and architecture of podosomes: a story of vertical oscillations, traveling waves and mesoscale coordination
12:00: Shimon Weiss, UCLA. Inorganic voltage nanosensors
12:30 – 1:30: Lunch
1:30: Joshua Zimmerberg, NIH. Dynamics of single molecules on the cell surface in exocytosis and endocytosis:cooperative behavior in geometric catalysis
2:00: Joerg Bewersdorf, Yale University. Advances in Live-cell Nanoscopy
2:30: Christopher Valley, UNM. Single molecule analysis of EGFR dynamics and dimerization using single particle tracking, hyper spectral microscopy, and super-resolution imaging
3:00: Coffee break
3:30: Yanli Liu, Sandia National Laboratories. Pulsed Stimulation via Microfluidics Reveals Short and Long-Term Molecular Memories in Mast Cells
3:50: Angela Wandinger-Ness, UNM. Signaling Microdomains and Cystic Kidney Disease
4:20: Gaudenz Danuser, UT Southwestern Medical Center. Coordinating morphodynamics in 3D cell migration
5:00 - 6:15: Poster Session & Refreshments
The event is sponsored by the New Mexico Spatiotemporal Modeling Center, a NIGMS National Center for Systems Biology, the Cancer Nanotechnology Training Center, a member of the NCI Alliance for Nanotechnology in Cancer, and by Sandia National Laboratories. Additional support comes from the UNM Cancer Center, the New Mexico Consortium, the UNM Center for Biomedical Engineering and the UNM Nanoscience and Microsystems Graduate Program.
Photos by Janet Oliver and Michael Grady.
Video credit: Roy Wroth